Calithera Biosciences Gains Exclusive, Worldwide License to Mars Symbioscience’s Arginase Inhibitors

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Tuesday, December 9, 2014

Calithera Biosciences Gains Exclusive, Worldwide License to Mars Symbioscience’s Arginase Inhibitors

South San Francisco, Calif., Dec.9, 2014 (GLOBE NEWSWIRE)-- Calithera Biosciences, Inc. (NASDAQ:CALA) announced today the signing of an exclusive global license agreement with Mars Symbioscience (“Symbioscience”), a division of Mars, Incorporated, granting Calithera rights to research, develop and commercialize Symbioscience’s portfolio of arginase inhibitors, discovered as part of Mars’ cocoa flavanol research program, for use in human healthcare. Symbioscience’s preclinical arginase inhibitor program will enhance Calithera’s efforts to submit an Investigational New Drug application for an arginase inhibitor with the FDA for the treatment of cancer near the end of 2015.

"We believe that drugs targeting immuno-oncology and tumor metabolism pathways have the potential to be transformational in the treatment of cancer, and at Calithera, we are dedicated to researching and developing potential first-in-class therapies that could significantly advance these promising fields of research," said Susan M. Molineaux, PhD, President and CEO, Calithera Biosciences. "I am particularly excited about this agreement because we believe we can apply our core expertise in tumor biology to rapidly advance Symbioscience’s potent and selective small-molecule arginase inhibitors into the clinic to develop a first-in-class immuno-oncology therapy for cancer patients.”

Click here to read the full press release.

Read more news from Mars Center for Cocoa Health Science, including the latest cocoa flavanol research

About Calithera Biosciences

Calithera Biosciences is a clinical-stage company focused on discovering and developing novel small molecule drugs directed against tumor metabolism and tumor immunology. Calithera's lead clinical candidate, CB-839, is a first-in-class inhibitor of glutaminase, a critical enzyme in tumor metabolism, and is currently being tested in patients with solid and hematological cancers. Calithera Biosciences is headquartered in South San Francisco. For more information about Calithera Biosciences, please visit

About Mars Center For Cocoa Health Science

For more than 20 years, and based on collaborating with a multidisciplinary group of international experts, Mars, Incorporated has been conducting comprehensive and innovative research with a network of scientific collaborators around the world to advance the understanding of cocoa flavanols and their health benefits for the purpose of improving human health. Building on decades of research in cocoa flavanols, the Mars Center for Cocoa Health Science (MCCHS) was formally established in 2012 as a Center of Excellence to pioneer, capture and share the latest scientific research in the field. MCCHS provides access to more than 20 years of gold standard research, over 140 published peer-reviewed scientific papers, videos, slides and other information that Mars, Incorporated and its collaborators have developed to advance cocoa flavanol understanding. For more information, please visit Follow us:

About Mars, Incorporated

In 1911, Frank C. Mars made the first Mars candies in his Tacoma, Washington kitchen and established Mars’ first roots as a confectionery company. In the 1920s, Forrest E. Mars, Sr. joined his father in business and together they launched the MILKY WAY® bar. In 1932, Forrest, Sr. moved to the United Kingdom with a dream of building a business based on the objective of creating a “mutuality of benefits for all stakeholders” – this objective serves as the foundation of Mars, Incorporated today. Based in McLean, Virginia, Mars has net sales of more than $33 billion, six business segments including Petcare, Chocolate, Wrigley, Food, Drinks, Symbioscience, and more than 75,000 Associates worldwide that are putting its Principles into action to make a difference for people and the planet through its performance.
For more information, please visit Follow us:,,,


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