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Microbiome

Evaluation at scale of microbiome-derived metabolites as biomarker of flavan-3-ol intake in epidemiological studies
Reviews

Absorption, metabolism, distribution and excretion of (-)-epicatechin: A review of recent findings.
Biological Effects

Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies
Biological Effects

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives
Biological Effects

Safety And Efficacy of Cocoa Flavanol Intake In Healthy Adults: A Randomized, Controlled, Double-masked Trial
Cardiovascular

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study
Chemistry

Total Synthesis of Proanthocyanidin A1, A2, and Their Stereoisomers
Absorption & Metabolism

Influence of sugar type on the bioavailability of cocoa flavanols.
Cardiovascular

Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans.
Analytical Methods

Structurally related (-)-epicatechin metabolites in humans: assessment using de novo chemically synthesized authentic standards.
Chemistry

The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo.
Chemistry

TNFalpha-induced NF-kappaB activation and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells.
Cardiovascular

Procyanidins protect Caco-2 cells from bile acid- and oxidant-induced damage.
Cardiovascular

Membrane effects of cocoa procyanidins in liposomes and Jurkat T cells.
Chemistry

Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins.