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Scientific Research
20 years of research The COSMOS trial Analytics Reporting cocoa flavanol content in research Research library
What are Cocoa Flavanols?
An introduction to cocoa flavanols Cocoa flavanols and chocolate
Cocoa Flavanol Effects
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Find our latest research on cocoa flavanols, in collaboration with a global network of scientific partners

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Cardiovascular

Biomarker-estimated flavan-3-ol intake is associated with lower blood pressure in cross-sectional analysis in EPIC Norfolk
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Absorption & Metabolism

Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake
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Absorption & Metabolism

Evaluation at scale of microbiome-derived metabolites as biomarker of flavan-3-ol intake in epidemiological studies
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Biological Effects

Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies
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Biological Effects

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives
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Biological Effects

Vasculoprotective Effects of Dietary Cocoa Flavanols in Patients on Hemodialysis: A Double–Blind, Randomized, Placebo–Controlled Trial
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Biological Effects

Safety And Efficacy of Cocoa Flavanol Intake In Healthy Adults: A Randomized, Controlled, Double-masked Trial
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Cardiovascular

Impact of Cocoa Flavanol Intake On Age-Dependent Vascular Stiffness In Healthy Men: A Randomized, Controlled, Double-masked Trial
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Biological Effects

Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study.
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Biological Effects

Selective removal of the violet color produced by anthocyanins in procyanidin-rich unfermented cocoa extracts.
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Biological Effects

Dietary factors and the risk for acute infant leukemia: evaluating the effects of cocoa-derived flavanols on DNA topoisomerase activity.
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Biological Effects

Dimeric procyanidins are inhibitors of NF-kappaB-DNA binding.
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Biological Effects

Cytotoxic effects of digalloyl dimer procyanidins in human cancer cell lines.
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Biological Effects

Effect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjects.
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Biological Effects

Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial.
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