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Published research

Find our latest research on cocoa flavanols, in collaboration with a global network of scientific partners

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Biological Effects

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives
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Nature - Scientific Reports logo View Abstract
Biological Effects

Vasculoprotective Effects of Dietary Cocoa Flavanols in Patients on Hemodialysis: A Double–Blind, Randomized, Placebo–Controlled Trial
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Clinical Journal of American Society of Nephrology logo View Abstract
Biological Effects

Safety And Efficacy of Cocoa Flavanol Intake In Healthy Adults: A Randomized, Controlled, Double-masked Trial
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The American Journal of Clinical Nutrition logo View Abstract
Cardiovascular

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study
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British Journal of Nutrition logo View Abstract
Cardiovascular

Impact of Cocoa Flavanol Intake On Age-Dependent Vascular Stiffness In Healthy Men: A Randomized, Controlled, Double-masked Trial
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American Aging Association logo View Abstract
Chemistry

Total Synthesis of Proanthocyanidin A1, A2, and Their Stereoisomers
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Organic Letters logo View Abstract
Brain/Cognitive Health

Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial
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The American Journal of Clinical Nutrition logo View Abstract
Brain/Cognitive Health

Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults
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Nature Neuroscience logo View Abstract
Analytical Methods

Analysis of Cocoa Flavanols and Procyanidins (DP 1-10) in Cocoa-Containing Ingredients and Products by Rapid Resolution Liquid Chromatography: A Single-Laboratory Validation.
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AOAC International logo View Abstract
Chemistry

Enantioselective synthesis of orthogonally protected (2R,3R)-(−)-epicatechin derivatives, key intermediates in the de novo chemical synthesis of (−)-epicatechin glucuronides and sulfates.
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Tetrahedron Letters logo View Abstract
Analytical Methods

Chemical Synthesis and Characterization of Epicatechin Glucuronides and Sulfates: Bioanalytical Standards for Epicatechin Metabolite Identification
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Absorption & Metabolism

Influence of sugar type on the bioavailability of cocoa flavanols.
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British Journal of Nutrition logo View Abstract
Biological Effects

Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study.
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Hypertension logo View Abstract
Chemistry

A versatile approach to the regioselective synthesis of diverse (−)-epicatechin-β-D-glucuronides
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Tetrahedron Letters logo View Abstract
Analytical Methods

Method for the determination of catechin and epicatechin enantiomers in cocoa-based ingredients and products by high-performance liquid chromatography: single-laboratory validation.
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AOAC International logo View Abstract