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Published research

Find our latest research on cocoa flavanols, in collaboration with a global network of scientific partners

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Chemistry

Total Synthesis of Proanthocyanidin A1, A2, and Their Stereoisomers
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Brain/Cognitive Health

Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial
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The American Journal of Clinical Nutrition logo View Abstract
Brain/Cognitive Health

Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults
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Analytical Methods

Analysis of Cocoa Flavanols and Procyanidins (DP 1-10) in Cocoa-Containing Ingredients and Products by Rapid Resolution Liquid Chromatography: A Single-Laboratory Validation.
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Chemistry

Enantioselective synthesis of orthogonally protected (2R,3R)-(−)-epicatechin derivatives, key intermediates in the de novo chemical synthesis of (−)-epicatechin glucuronides and sulfates.
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Analytical Methods

Chemical Synthesis and Characterization of Epicatechin Glucuronides and Sulfates: Bioanalytical Standards for Epicatechin Metabolite Identification
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Absorption & Metabolism

Influence of sugar type on the bioavailability of cocoa flavanols.
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British Journal of Nutrition logo View Abstract
Biological Effects

Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study.
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Chemistry

A versatile approach to the regioselective synthesis of diverse (−)-epicatechin-β-D-glucuronides
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Analytical Methods

Method for the determination of catechin and epicatechin enantiomers in cocoa-based ingredients and products by high-performance liquid chromatography: single-laboratory validation.
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AOAC International logo View Abstract
Cardiovascular

Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans.
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The American Journal of Clinical Nutrition logo View Abstract
Analytical Methods

Structurally related (-)-epicatechin metabolites in humans: assessment using de novo chemically synthesized authentic standards.
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Biological Effects

Selective removal of the violet color produced by anthocyanins in procyanidin-rich unfermented cocoa extracts.
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Journal of Food Science logo View Abstract
Analytical Methods

Physicochemical properties of acidified skim milk gels containing cocoa flavanols.
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Journal of Agriculture and Food Chemistry logo View Abstract
Chemistry

The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo.
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