Published research
Find our latest research on cocoa flavanols, in collaboration with a global network of scientific partners
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Brain/Cognitive Health
The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway.
Brain/Cognitive Health
Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort.
Cardiovascular
Dose-related effects of flavanol-rich cocoa on blood pressure.
Chemistry
Enantioselective syntheses of sulfur analogues of flavan-3-Ols.
Chemistry
Synthesis of [2-13C, 4-13C]-(2R,3S)-catechin and [2-13C, 4-13C]-(2R,3R)-epicatechin
Cardiovascular
Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease.
Cardiovascular
Impact of cocoa flavanol consumption on blood pressure responsiveness to exercise.
Biological Effects
Dietary factors and the risk for acute infant leukemia: evaluating the effects of cocoa-derived flavanols on DNA topoisomerase activity.
Biological Effects
Dimeric procyanidins are inhibitors of NF-kappaB-DNA binding.
Analytical Methods
Method performance and multi-laboratory assessment of a normal phase high pressure liquid chromatography-fluorescence detection method for the quantitation of flavanols and procyanidins in cocoa and chocolate containing samples.
Microbiome
Cocoa flavanols and procyanidins can modulate the lipopolysaccharide activation of polymorphonuclear cells in vitro.
Biological Effects
Cytotoxic effects of digalloyl dimer procyanidins in human cancer cell lines.
Chemistry
TNFalpha-induced NF-kappaB activation and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells.
Cardiovascular
Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo.
Biological Effects
