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Published research

Find our latest research on cocoa flavanols, in collaboration with a global network of scientific partners

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Reviews

Recommending flavanols and procyanidins for cardiovascular health: current knowledge and future needs.
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Brain/Cognitive Health

The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway.
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Brain/Cognitive Health

Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort.
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British Association for Psychopharmacology logo View Abstract
Cardiovascular

Dose-related effects of flavanol-rich cocoa on blood pressure.
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Journal of Human Hypertension logo View Abstract
Chemistry

Enantioselective syntheses of sulfur analogues of flavan-3-Ols.
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Molecules logo View Abstract
Chemistry

Synthesis of [2-13C, 4-13C]-(2R,3S)-catechin and [2-13C, 4-13C]-(2R,3R)-epicatechin
Journal of Labelled Compounds and Radiopharmaceuticals logo View Abstract
Cardiovascular

Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease.
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Journal of the American College of Cardiology logo View Abstract
Cardiovascular

Impact of cocoa flavanol consumption on blood pressure responsiveness to exercise.
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British Journal of Nutrition logo View Abstract
Biological Effects

Dietary factors and the risk for acute infant leukemia: evaluating the effects of cocoa-derived flavanols on DNA topoisomerase activity.
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Society for Experimental Biology and Medicine logo View Abstract
Biological Effects

Dimeric procyanidins are inhibitors of NF-kappaB-DNA binding.
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Biochemical Pharmacology logo View Abstract
Analytical Methods

Method performance and multi-laboratory assessment of a normal phase high pressure liquid chromatography-fluorescence detection method for the quantitation of flavanols and procyanidins in cocoa and chocolate containing samples.
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Journal of Chromatography A logo View Abstract
Microbiome

Cocoa flavanols and procyanidins can modulate the lipopolysaccharide activation of polymorphonuclear cells in vitro.
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Journal of Medicinal Food logo View Abstract
Biological Effects

Cytotoxic effects of digalloyl dimer procyanidins in human cancer cell lines.
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The Journal of Nutritional Biochemistry logo View Abstract
Chemistry

TNFalpha-induced NF-kappaB activation and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells.
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Archives of Biochemistry and Biophysics logo View Abstract
Cardiovascular

Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo.
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Archives of Biochemistry and Biophysics logo View Abstract