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Published research

Find our latest research on cocoa flavanols, in collaboration with a global network of scientific partners

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Cardiovascular

Biomarker-estimated flavan-3-ol intake is associated with lower blood pressure in cross-sectional analysis in EPIC Norfolk
Absorption & Metabolism

Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake
Absorption & Metabolism

Evaluation at scale of microbiome-derived metabolites as biomarker of flavan-3-ol intake in epidemiological studies
Biological Effects

Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies
Biological Effects

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives
Biological Effects

Vasculoprotective Effects of Dietary Cocoa Flavanols in Patients on Hemodialysis: A Double–Blind, Randomized, Placebo–Controlled Trial
Cardiovascular

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study
Cardiovascular

Impact of Cocoa Flavanol Intake On Age-Dependent Vascular Stiffness In Healthy Men: A Randomized, Controlled, Double-masked Trial
Biological Effects

Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study.
Cardiovascular

Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans.
Reviews

Recommending flavanols and procyanidins for cardiovascular health: current knowledge and future needs.
Brain/Cognitive Health

The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway.
Cardiovascular

Dose-related effects of flavanol-rich cocoa on blood pressure.
Cardiovascular

Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease.
Cardiovascular

Impact of cocoa flavanol consumption on blood pressure responsiveness to exercise.