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Scientific Research
20 years of research The COSMOS trial Analytics Reporting cocoa flavanol content in research Research library
What are Cocoa Flavanols?
An introduction to cocoa flavanols Cocoa flavanols and chocolate
Cocoa Flavanol Effects
Cardiovascular health Cognitive health
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Published research

Find our latest research on cocoa flavanols, in collaboration with a global network of scientific partners

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Cardiovascular

Biomarker-estimated flavan-3-ol intake is associated with lower blood pressure in cross-sectional analysis in EPIC Norfolk
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Analytical Methods

Reliable, accessible and transferable method for the quantification of flavanols and procyanidins in foodstuffs and dietary supplements†
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Absorption & Metabolism

Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake
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Absorption & Metabolism

Evaluation at scale of microbiome-derived metabolites as biomarker of flavan-3-ol intake in epidemiological studies
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Analytical Methods

Use of LC-MS for the quantitative analysis of (poly)phenol metabolites does not necessarily yield accurate results: Implications for assessing existing data and conducting future research.
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Reviews

Absorption, metabolism, distribution and excretion of (-)-epicatechin: A review of recent findings.
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Biological Effects

Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies
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Biological Effects

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives
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Biological Effects

Vasculoprotective Effects of Dietary Cocoa Flavanols in Patients on Hemodialysis: A Double–Blind, Randomized, Placebo–Controlled Trial
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Biological Effects

Safety And Efficacy of Cocoa Flavanol Intake In Healthy Adults: A Randomized, Controlled, Double-masked Trial
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Cardiovascular

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study
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Cardiovascular

Impact of Cocoa Flavanol Intake On Age-Dependent Vascular Stiffness In Healthy Men: A Randomized, Controlled, Double-masked Trial
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Chemistry

Total Synthesis of Proanthocyanidin A1, A2, and Their Stereoisomers
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Brain/Cognitive Health

Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial
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Brain/Cognitive Health

Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults
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