Search

Search

Search logo

Search

Scientific Research
20 years of research The COSMOS trial Analytics Reporting cocoa flavanol content in research Our Partners
What are Cocoa Flavanols?
An introduction to cocoa flavanols Cocoa flavanols and chocolate
Cocoa Flavanol Effects
Cardiovascular health Cognitive health
Who We Are
About Mars Edge Mars, Incorporated science and research policy Cocoa flavanol products Lead Experts
Library
Publications
News
Press releases
Blog
The Cocoa Flavanol Science Blog

Published research

Find our latest research on cocoa flavanols, in collaboration with a global network of scientific partners

Filter Filter by
Analytical Methods

Standardizing testing for dietary bioactives with a tool to compare & estimate cocoa flavanol content
(opens in a new tab)
Royal Society of Chemistry logo View Abstract
Brain/Cognitive Health

Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial
(opens in a new tab)
Nature - Scientific Reports logo View Abstract
Cardiovascular

Biomarker-estimated flavan-3-ol intake is associated with lower blood pressure in cross-sectional analysis in EPIC Norfolk
(opens in a new tab)
Nature - Scientific Reports logo View Abstract
Analytical Methods

Reliable, accessible and transferable method for the quantification of flavanols and procyanidins in foodstuffs and dietary supplements†
(opens in a new tab)
Royal Society of Chemistry logo View Abstract
Absorption & Metabolism

Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake
(opens in a new tab)
Nature - Scientific Reports logo View Abstract
Absorption & Metabolism

Evaluation at scale of microbiome-derived metabolites as biomarker of flavan-3-ol intake in epidemiological studies
(opens in a new tab)
Nature - Scientific Reports logo View Abstract
Analytical Methods

Use of LC-MS for the quantitative analysis of (poly)phenol metabolites does not necessarily yield accurate results: Implications for assessing existing data and conducting future research.
(opens in a new tab)
View Abstract
Reviews

Absorption, metabolism, distribution and excretion of (-)-epicatechin: A review of recent findings.
(opens in a new tab)
View Abstract
Biological Effects

Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies
(opens in a new tab)
The American Journal of Clinical Nutrition logo View Abstract
Biological Effects

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives
(opens in a new tab)
Nature - Scientific Reports logo View Abstract
Biological Effects

Vasculoprotective Effects of Dietary Cocoa Flavanols in Patients on Hemodialysis: A Double–Blind, Randomized, Placebo–Controlled Trial
(opens in a new tab)
Clinical Journal of American Society of Nephrology logo View Abstract
Biological Effects

Safety And Efficacy of Cocoa Flavanol Intake In Healthy Adults: A Randomized, Controlled, Double-masked Trial
(opens in a new tab)
The American Journal of Clinical Nutrition logo View Abstract
Cardiovascular

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study
(opens in a new tab)
British Journal of Nutrition logo View Abstract
Cardiovascular

Impact of Cocoa Flavanol Intake On Age-Dependent Vascular Stiffness In Healthy Men: A Randomized, Controlled, Double-masked Trial
(opens in a new tab)
American Aging Association logo View Abstract
Chemistry

Total Synthesis of Proanthocyanidin A1, A2, and Their Stereoisomers
(opens in a new tab)
Organic Letters logo View Abstract