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The Cocoa Flavanol Science Blog

Published research

Find our latest research on cocoa flavanols, in collaboration with a global network of scientific partners

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Biological Effects

Flavan-3-ol-methylxanthine interactions: Modulation of flavan-3-ol bioavailability in volunteers with a functional colon and an ileostomy
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Other Biological Effects

Cocoa Flavanol Supplementation and the Effect on Insulin Resistance in Females Who Are Overweight or Obese: A Randomized, Placebo-Controlled Trial
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Cardiovascular

Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
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The American Journal of Clinical Nutrition logo View Abstract
Analytical Methods

Standardizing testing for dietary bioactives with a tool to compare & estimate cocoa flavanol content
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Royal Society of Chemistry logo View Abstract
Brain/Cognitive Health

Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial
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Nature - Scientific Reports logo View Abstract
Cardiovascular

Biomarker-estimated flavan-3-ol intake is associated with lower blood pressure in cross-sectional analysis in EPIC Norfolk
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Nature - Scientific Reports logo View Abstract
Analytical Methods

Reliable, accessible and transferable method for the quantification of flavanols and procyanidins in foodstuffs and dietary supplements†
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Royal Society of Chemistry logo View Abstract
Absorption & Metabolism

Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake
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Nature - Scientific Reports logo View Abstract
Absorption & Metabolism

Evaluation at scale of microbiome-derived metabolites as biomarker of flavan-3-ol intake in epidemiological studies
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Nature - Scientific Reports logo View Abstract
Analytical Methods

Use of LC-MS for the quantitative analysis of (poly)phenol metabolites does not necessarily yield accurate results: Implications for assessing existing data and conducting future research.
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Reviews

Absorption, metabolism, distribution and excretion of (-)-epicatechin: A review of recent findings.
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Biological Effects

Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies
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The American Journal of Clinical Nutrition logo View Abstract
Biological Effects

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives
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Nature - Scientific Reports logo View Abstract
Biological Effects

Vasculoprotective Effects of Dietary Cocoa Flavanols in Patients on Hemodialysis: A Double–Blind, Randomized, Placebo–Controlled Trial
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Clinical Journal of American Society of Nephrology logo View Abstract
Biological Effects

Safety And Efficacy of Cocoa Flavanol Intake In Healthy Adults: A Randomized, Controlled, Double-masked Trial
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The American Journal of Clinical Nutrition logo View Abstract