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An introduction to cocoa flavanols Cocoa flavanols and chocolate
Cardiovascular & heart health effects of cocoa flavanols The COSMOS trial Cognitive & brain health effects of cocoa flavanols The COSMOS-Web trial Uncover the benefits of flavanols Analytical methods of cocoa flavanol research Research publications
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Research publications

Find our latest research on cocoa flavanols, in collaboration with a global network of scientific partners

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Analytical Methods

Reliable, accessible and transferable method for the quantification of flavanols and procyanidins in foodstuffs and dietary supplements†
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Absorption & Metabolism

Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake
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Absorption & Metabolism

Evaluation at scale of microbiome-derived metabolites as biomarker of flavan-3-ol intake in epidemiological studies
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Analytical Methods

Use of LC-MS for the quantitative analysis of (poly)phenol metabolites does not necessarily yield accurate results: Implications for assessing existing data and conducting future research
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Reviews

Absorption, metabolism, distribution and excretion of (-)-epicatechin: A review of recent findings
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Biological Effects

Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies
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Biological Effects

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives
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Biological Effects

Vasculoprotective Effects of Dietary Cocoa Flavanols in Patients on Hemodialysis: A Double–Blind, Randomized, Placebo–Controlled Trial
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Biological Effects

Safety And Efficacy of Cocoa Flavanol Intake In Healthy Adults: A Randomized, Controlled, Double-masked Trial
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Cardiovascular

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study
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Cardiovascular

Impact of Cocoa Flavanol Intake On Age-Dependent Vascular Stiffness In Healthy Men: A Randomized, Controlled, Double-masked Trial
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Chemistry

Total Synthesis of Proanthocyanidin A1, A2, and Their Stereoisomers
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Brain/Cognitive Health

Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial
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Brain/Cognitive Health

Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults
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Analytical Methods

Analysis of Cocoa Flavanols and Procyanidins (DP 1-10) in Cocoa-Containing Ingredients and Products by Rapid Resolution Liquid Chromatography: A Single-Laboratory Validation
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