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Chemistry

Enantioselective synthesis of orthogonally protected (2R,3R)-(−)-epicatechin derivatives, key intermediates in the de novo chemical synthesis of (−)-epicatechin glucuronides and sulfates.
Analytical Methods

Chemical Synthesis and Characterization of Epicatechin Glucuronides and Sulfates: Bioanalytical Standards for Epicatechin Metabolite Identification
Absorption & Metabolism

Influence of sugar type on the bioavailability of cocoa flavanols.
Biological Effects

Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study.
Analytical Methods

Method for the determination of catechin and epicatechin enantiomers in cocoa-based ingredients and products by high-performance liquid chromatography: single-laboratory validation.
Cardiovascular

Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans.
Analytical Methods

Structurally related (-)-epicatechin metabolites in humans: assessment using de novo chemically synthesized authentic standards.
Biological Effects

Selective removal of the violet color produced by anthocyanins in procyanidin-rich unfermented cocoa extracts.
Analytical Methods

Physicochemical properties of acidified skim milk gels containing cocoa flavanols.
Chemistry

The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo.
Microbiome

Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study.
Reviews

Recommending flavanols and procyanidins for cardiovascular health: current knowledge and future needs.
Brain/Cognitive Health

The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway.
Brain/Cognitive Health

Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort.
Cardiovascular

Dose-related effects of flavanol-rich cocoa on blood pressure.